Microbial 1β-Hydroxylation of Digitoxigenin
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چکیده
منابع مشابه
Microbial hydroxylation of 16α, 17α-epoxyprogesterone by Penicillium decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
متن کاملMicrobial hydroxylation of 16α, 17α-epoxyprogesterone by Penicillium decumbens
Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...
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The hydroxylation of the indole-type alkaloids, yohimbine, alpha-yohimbine, beta-yohimbine, and corynanthine, was achieved with several genera of higher fungi and species of Streptomyces. Microorganisms were found which monohydroxylated these compounds in three different positions. The site of hydroxylation was strain-specific for two strains of Cunninghamella echinulata and C. bainieri.
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Microorganisms were examined for their potential to hydroxylate the oxygenated monoterpene 1,4-cineole. Using gas chromatography and thin-layer chromatography, screening experiments revealed that hydroxylation at position 2 was the most commonly observed microbial transformation reaction. In most microorganisms, the predominant alcohol metabolite was the 2-endo-alcohol isomer. Preparative-scale...
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Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15alpha-hydroxyprogesterone and 15alpha-hydroxydeoxycorticosterone.
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1961
ISSN: 0002-1369
DOI: 10.1080/00021369.1961.10857838